New Migraine Study Results....

For those of you who suffer from migraines, like I do, you might have missed the results of a couple of new studies, as reported on Yahoo:

"The study, published Sunday in the British journal Nature Genetics, is the largest to date of its kind. It found variations in three genes that showed up more frequently in migraine patients.

Two of them, known as PRDM16 and TRPM8, were specific to migraines, as opposed to other kinds of headaches.

TRPM8, in addition, was linked to migraines only in women. Earlier studies have shown that the same gene contains the genetic "blueprint" for a pain sensor, in both men and women.

The third suspect gene, LRP1, is involved in sensing the external world and in chemical pathways inside the brain.

Photo from Collection Area: http://collectionarea.com/2011/04/13/migraine-headache-2/

"The brain of a person with migraine responds differently to certain stimuli, their nerve cells 'talk' differently to each other," explained Shuerks in an email.

"Many neurotransmitters are involved in this cross-talk and some seem to have a special role in migraines. LRP1 interacts with some of these neurotransmitter pathways and may thus modulate nerve responses that promote or suppress migraine attacks."

The findings, published in Nature Genetics, were replicated in two smaller population-based studies, one in the Netherlands and the other in Germany, and in a clinical group followed by the International Headache Genetics Consortium.

"Inheritance of any of the genetic variants alters migraine risk by about 10 to 15 percent," said Schuerks.

The influence of these genes is probably not large enough to be immediately used as a diagnostic tool. But the result "is an advancement of the understanding of migraine biology," he said. "